The soluble building blocks of these structures are amyloid-β (Aβ) peptides for plaques and tau for tangles. Amyloid-β peptides are proteolytic fragments of the transmembrane amyloid precursor protein, whereas tau is a brain-specific, axon-enriched microtubule-associated protein.

2020年8月10日 · Here, drawing from extensive human and disease model data, we highlight the latest evidence base pertaining to the complex Aβ–tau interaction and underscore its crucial importance to...

We discuss novel findings showing binding of both Aβ and tau oligomers to amyloid-β protein precursor (AβPP), and the requirement for the presence of this protein for both Aβ and tau to enter neurons and induce abnormal synaptic function and memory.

Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer’s disease (AD) and, as such, have become the focus of therapeutic development. Recent research, however, shows that these proteins have been highly conserved ...

In this review, we provide an overview of the physiological role of amyloid-beta and tau proteins, mechanisms underlying their accumulation, and pathogenesis in diseases including cardiovascular diseases (CVD), cerebral amyloid angiopathy (CAA) and stroke, cancer, diabetes, retinal diseases, Parkinson’s disease (PD), traumatic brain injury ...

2010年12月31日 · Here, we review novel findings that have shifted our understanding of the role of tau in the pathogenesis of Alzheimer's disease towards being a crucial partner of amyloid-β.

2022年5月4日 · Long-range and local interactions between amyloid-β (Aβ) and tau promote the spread of tau pathology in Alzheimer disease (AD), new work shows. The findings resolve long-standing questions...

2023年11月1日 · Researchers are currently investigating how these two proteins interact to lead to the development of Alzheimer’s. One emerging theory suggests that beta-amyloid plaques trigger tau tangles to...

Emerging evidence suggests that Alzheimer’s-related brain changes may result from a complex interplay among abnormal tau and beta-amyloid proteins and several other factors. It appears that abnormal tau accumulates in specific brain regions involved in memory.

Early breakthroughs in AD research led to the discovery of amyloid-β as the major component of senile plaques and tau protein as the major component of NFTs.