Down-regulation of JAK1 by RNA interference inhibits growth of …
Our study suggests that JAK1 expression and phosphorylation is abnormal in NSCLC tissues. The knockdown of JAK1 significantly inhibits tumourigenicity of the A549 cell line and demonstrates that crosstalk between the JAK1 and PI3K/mTOR pathways is involved.
3716 - Gene ResultJAK1 Janus kinase 1 [ (human)] - National …
Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. Mutations in JAK1 were found in one (7%) myeloid leukemia-Down Syndrome patient (D625R) and in one (3%) Down Syndrome-acute lymphoblastic leukemia patient (V651 M).
通过 RNA 干扰下调 JAK1 抑制肺癌细胞系 A549 的生长并干扰 …
a549 细胞中的 jak1 敲低显着抑制细胞增殖和侵袭，同时促进 g0/g1 期细胞停滞（均 p < 0.05）。 异种移植模型显示，与正常对照相比，JAK1 抑制抑制了肿瘤生长（P < 0.05）。
Swertia chirayita suppresses the growth of non-small cell lung …
chirayita ethanolic extract (Sw-EtOH) on non-small cell lung cancer (NSCLC) A549 cells during this exploratory study. The results elucidated that S. chirayita extract induced toxic effects within lung cancer cells by ~1 fold during cytotoxicity and LDH release assay at a …
科研 | Cancer Res.: 单细胞蛋白质组学分析: 联合抑制AXL和JAK1是 …
2024年4月26日 · 磷酸化的stat3 (pstat3)水平在a549处理的细胞中显著增加，而jak1即使在tp-0903存在的情况下也稳定地保持高活性(图2b)，与毛细管wes蛋白分析结果一致(补充图s3和s4)，该处理抑制了a549细胞的三个主要亚群中的smad4(# 6-8)(图2b)，而smad2的上调可能是通过pstat3的增加而促进的 ...
Cancer Res | 肺癌单细胞蛋白组学分析，实现肺癌分型及联合用药 …
2020年10月27日 · no.1 抗axl治疗后jak1-stat3通路的代偿性激活. 研究人员首先测试了axl抑制（tp-0903）对两种转移性肺癌细胞a549和h2009细胞系生长的影响，研究发现，随着抑制剂浓度增加，
In this study, we explored the role of JAK1 in the non-small cell lung cancer (NSCLC) cell line A549 and its molecular crosstalk with the phosphatidyl inositol-3-kinase (PI3K)/ mammalian target of the rapamycin (mTOR) pathway. One hundred and two NSCLC and 50 normal lung specimens were collected after surgical resection.
Down-regulation of JAK1 by RNA interference inhibits growth
2011年8月23日 · The knockdown of JAK1 significantly inhibits tumourigenicity of the A549 cell line and demonstrates that crosstalk between the JAK1 and PI3K/mTOR pathways is involved. The mammalian Janus kinase (JAK) family plays a critical role in cytokine/growth factor signalling pathways and is associated with human cancers.
Jak inhibition, but not Stat1 knockdown, blocks the ... - PubMed
Our findings suggest that the proapoptotic actions of IFN-gamma in A549 cells occur downstream of Jak1 activation by a noncanonical pathway that does not involve the Jak1 target, Stat1. Non-small cell lung cancer (NSCLC) is highly resistant to chemotherapy and radiation.
虾青素通过阻断JAK1 / STAT3途径抑制A549肺癌细胞增殖并促进 …
结论虾青素可通过靶向JAK1 / STAT3信号通路来有效抑制A549肺癌细胞的生长。 [Astaxanthin inhibits proliferation and promotes apoptosis of A549 lung cancer cells via blocking JAK1/STAT3 pathway]. Objective To investigate the anti-tumor effects of astaxanthin on A549 lung cancer cells and the related mechanisms.