Background: The lysosome plays a vitally crucial role in tumor development and is a major participant in the cell death process, involving aberrant functional and structural changes. However, there ...

School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan 523808, P. R. China Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key ...

While PSEN1 prefers to bask on the cell surface and sometimes ventures into the early endosomes, PSEN2 contains a sorting sequence that strictly restricts it to late endosomes and lysosomes. As such, ...

Hippocampal neurons with staining for endosomes (turquoise and purple) and lysosomes (yellow ... including APP, PSEN1, and PSEN2. The impact of PSEN2 mutations has remained less understood ...

This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).

Cathepsin D (CTSD) is a lysosomal protease important for the degradation of various substrates, including disease-associated proteins like α-synuclein (a-syn), amyloid precursor protein (APP) and tau, ...