Insights into the structures could lead to improved treatment strategies for transthyretin amyloidosis, a progressive, fatal disease in men.

Drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed to tackle AD ...

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy ...

Now, Scripps Research scientists have uncovered new structures of transthyretin. Their findings, published in Nature Structural & Molecular Biology on January 22, 2025, show how the three-dimension ...

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy transthyretin moves hormones through blood and spinal fluid, misfolded ...

Yet despite decades of research, no treatment has been created that arrests Alzheimer’s cognitive deterioration, let alone reverses it. That dismal lack of progress is partly because of the infinite ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study.

Professor John Hardy (UCL Queen Square Institute of Neurology) developed the amyloid cascade hypothesis for Alzheimer's, where build-ups of beta-amyloid plaques in the brain are the primary cause of ...

In 1991 John Hardy, a neuroscientist now at University College, London, and his late colleague David Allsop (then at Queen’s University, Belfast) thus proposed the amyloid cascade hypothesis.

Prior research supports the hypothesis that dairy peptides and fatty ... The study has revealed Camembert's potential to cut down levels of the amyloid-beta protein, an Alzheimer’s and dementia ...

Over the past few years, data and drugs associated with the amyloid hypothesis have been mired in various controversies relating to data integrity, regulatory approval, and drug safety.