Insights into the structures could lead to improved treatment strategies for transthyretin amyloidosis, a progressive, fatal disease in men.

Drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed to tackle AD ...

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy ...

Now, Scripps Research scientists have uncovered new structures of transthyretin. Their findings, published in Nature Structural & Molecular Biology on January 22, 2025, show how the three-dimension ...