Using a unique, zebrafish-based phenotypic screening ... Over the past decade, phenotype-based drug discovery has experienced a revival as an integral part of drug discovery alongside target ...

We are a group of Purdue faculty using zebrafish in our research. Our research interest covers a wide variety of topics, including cancer, development, disease modeling, drug discovery, immunology, ...

In zebrafish, ketamine causes changes a brain circuit involved in "giving up." That may help explain how the drug helps people with depression.

The discovery and development of drugs in pharmacological research – including the risk assessment of active substances in ...

Because zebrafish are small and translucent, researchers can image each animal's entire brain to better track the drug's effects. The Ahrens Lab had shown in earlier work that zebrafish exhibit a ...

A second, interlinked research theme is analysis of the Adgrg6 signalling pathway and drug discovery. Adgrg6 is a human disease gene, and the zebrafish protein has roles both in the inner ear and in ...

researchers may want to use zebrafish to study how particular psychiatric drugs interact with the brain. AHRENS: Understanding the biology mechanistically is also important for drug discovery.

researchers may want to use zebrafish to study how particular psychiatric drugs interact with the brain. AHRENS: Understanding the biology mechanistically is also important for drug discovery.

What makes this research particularly exciting is its creative approach to drug discovery ... team turned to an unlikely ...

Researchers from the Hubrecht Institute and their collaborators at other institutions have used a protein from zebrafish dubbed Hmga1 which plays a key role in heart regeneration, to reactivate ...