Cancer immunotherapy has represented a significant advancement in cancer treatment; however, many patients experience relapse or develop resistance to this treatment. Bispecific antibodies that ...

gp96 is a powerful immune stimulator that directs antigen cross-presentation and enhances T cell costimulation on activated dendritic cells. “We formed Heat with the singular goal of developing ...

B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs). B7-H3-CARs ...

Figure 1: Ipilimumab stimulates antitumor immunity by blocking CTLA4, a natural brake on T cells, and allowing their unimpeded 'costimulation'. The one controversy in the phase 3 trial was the ...

A study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor ...

Currently available biologics include TNF-α blockers, agents that target IL-1 and IL-6, T-cell costimulation inhibitors and antibodies against the CD20 molecule present on B cells. In this review ...

H-Y responses were elicited by intraperitoneal injection of 5 x 106 male spleen cells into female recipients. ELISpot Assay. IFN-γ-secreting T cells were enumerated using MultiScreen-IP ELISpot ...