Protein phosphorylation is a covalent post-translational modification event that is essential for regulation and maintenance of most biological processes in eukaryotes 1. Conventionally ...

Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme involved in glycogen ... Figure 4: The molecular mechanism by which phosphorylation inhibits GSK3. Figure 5: Several ...

Prolonged exercise and high-intensity exercise lead to an increase in key phosphorylation enzymes that ultimately cause tight junction dysfunction, but the mechanisms are different. The purpose of ...

Enzymes can be regulated by various means, such as allosteric regulation (binding of effector molecules), covalent modification (e.g., phosphorylation), and changes in pH or temperature. The Michaelis ...

Furthermore, they elucidated that the activation of calcium/calmodulin-dependent kinase II (CaMKII), a protein ...

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This led to a decrease in PDHA1 S293 phosphorylation and an increase in PDH enzyme activity, promoting oxidative phosphorylation and reducing glycolysis. The clinical relevance of PDK1 Y163 ...