While PSEN1 prefers to bask on the cell surface and sometimes ventures into the early endosomes, PSEN2 contains a sorting sequence that strictly restricts it to late endosomes and lysosomes. As such, ...

Hippocampal neurons with staining for endosomes (turquoise and purple) and lysosomes (yellow ... including APP, PSEN1, and PSEN2. The impact of PSEN2 mutations has remained less understood ...