2016年12月，四川大学华西医院在Scientific Reports（IF3.8001/2区）期刊上发表了一篇论文。在发表9年后，因图片与早期论文重复在pubpeer上被读者质疑。 论文题为“Crystal structure-based ...

PARP inhibitor treatment can induce various resistance mechanisms, including re-activating BRCA mutations, mutations in HR-inhibiting genes and upregulation of drug efflux pumps. Clinical ...

Other PARP inhibitors have validated the mechanism of action in cancers of the ovary, breast, prostate and pancreas. IDX-1197 has several key advantages over those commercially available PARP ...

The PARP & DDR Inhibitors Summit is your only industry ... to decipher the entangled network of DNA damage response mechanisms, including multiple DNA repair pathways, damage tolerance processes ...

Results from the PAOLA-1 study showed that the PARP inhibitor drug significantly increased the time women lived without disease progression when added to the standard-of-care, Genentech’s ...