Osteoblast activities such as laying down bone matrix ... osteoblast life-lengthening IGFs out of action; and the genes for osteoclast stimulators, such as IL-6 and IL-11. In addition, the ...
Osteoblasts/stromal cells produce osteoclast differentiation factor (ODF) or stromal osteoclast forming activity (SOFA) as a membrane-associated factor in response to osteotropic factors ...
The results indicated that while promoting osteoblast activity and bone formation, iSN40 simultaneously inhibited osteoclast differentiation and suppressed bone resorption.