In brief, autophagy is a ubiquitous process in eukaryotic cells that results in the breakdown of cytoplasm within the lysosome in response to stress conditions and that allows the cell to adapt to ...

Then, depending on the stimuli that initiated the autophagy process, the cargo is either degraded or recycled. In 2004, fifty years after Novikoff and de Duve observed lysosomes under the electron ...

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Figure 1. Entosis promotes cell competition. (A) Entosis ...

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste.

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

[76] It is a degradative, membrane-based system by which long-lived intracellular products are removed and turned over via the lysosome. Autophagy is highly conserved; in a unicellular world ...

Autophagy is an evolutionally conserved cellular process to maintain homeostasis in eukaryotes. Double-membraned autophagosomes engulf cytosolic cargoes to deliver them to the lysosome or vacuole for ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...

Among these, the transcription factors EB (TFEB) and E3 (TFE3) caught Tan’s attention, because their activation coincided with genes that increased lysosome production. TFEB is also an ancient ...