近期，加拿大多伦多大学与英矽智能共同主导的一项研究首次展示量子计算和人工智能在变革药物发现流程方面的潜力。在这项研究中，科学家将量子计算模型与经典计算模型和生成式人工智能相结合，通过对庞大数据集的训练、生成和筛选，探索更广泛的化学可能性，发现靶向“不 ...

Revolution Medicines Inc. has synthesized macrocyclic compounds acting as GTPase KRAS, NRAS, HRAS and their mutant inhibitors reported to be useful for the treatment of cancer. BioWorld Science Cancer ...

Panel A summarizes the conventional model of how oncogenic RAS guanosine triphosphatases (i.e., Kirsten rat sarcoma viral oncogene homologue [KRAS], neuroblastoma RAS viral oncogene homologue ...

RAS基因，也称为鼠肉瘤病毒，包括与人类肿瘤相关的三个基因（KRAS、HRAS和NRAS）。其中，KRAS在癌症中的突变发生率最高，约占病例的80-85%。影响细胞 ...

Researchers from Boehringer Ingelheim Pharma GmbH & Co KG have published preclinical data for their novel pan-KRAS inhibitors ...

For example, disease-causing gene variants (PVs) in the HRAS gene cause Costello syndrome and PVs in the KRAS gene cause ...