HSCT may be a suitable treatment for X-linked ALD adults with early signs of cerebral involvement. Very long-chain fatty acid levels and adrenoleukodystrophy protein (ALDP)-deficiency are strongly ...

An exploratory objective assessed VK0214's effects on plasma levels of very long-chain fatty acids (VLCFAs), the biomarkers ...

Quentin M. Anstee, B.Sc., M.B.B.S., Ph.D., M.R.C.P.; Ann K. Daly, B.Sc., Ph.D.; Christopher P. Day, B.A.,M.B., B.Chir.,M.A. (Cambridge), Ph.D.,M.D., F.R.C.P., F.Med ...

X-Linked Adrenoleukodystrophy (X-ALD) is a genetic disorder caused by mutations in the ABCD1 gene, which is responsible for transporting very-long-chain fatty acids ...

In individuals with ALD, levels of short-chain fatty acids (SCFAs), typically ... The production of bile acids (BAs) is regulated by the farnesoid X receptor (FXR); however, alcohol diminishes ...

"ALD is a disease that prevents the body from breaking down long-chain fatty acids, causing them to build ... their son had X-linked Adrenoleukodystrophy, or ALD, a rare and serious genetic ...

Short-chain fatty acids (SCFAs) serve as key signaling molecules linking gut microbiota and host health. Microbially produced ...

ALD prevents the body from breaking down very long chain fatty acids (VLCFAs) which causes damage to the myelin sheath, the membrane that surrounds nerve fibers in the brain and spinal cord.

Research reveals links between dietary fatty acids and kidney stone risk, highlighting the need for targeted dietary ...

plasma levels of very long-chain fatty acids (VLCFAs) and other lipids were significantly reduced compared to placebo. VLCFAs are considered biomarkers of disease in patients with X-ALD.

Omega-3 fatty acids are a type of essential fats linked to many health benefits, such as heart health, reduced inflammation, ...

Fatty acids are organic acids with at least one carboxyl (-C(=O)OH, -COOH or -CO2H) group and a long carbon chain that can be joined by double bonds, as in unsaturated fatty acids, or single bonds ...