X-Linked Adrenoleukodystrophy (X-ALD) is a genetic disorder caused by mutations in the ABCD1 gene, which is responsible for transporting very-long-chain fatty acids ...

HSCT may be a suitable treatment for X-linked ALD adults with early signs of cerebral involvement. Very long-chain fatty acid levels and adrenoleukodystrophy protein (ALDP)-deficiency are strongly ...

An exploratory objective assessed VK0214's effects on plasma levels of very long-chain fatty acids (VLCFAs), the biomarkers ...

In individuals with ALD, levels of short-chain fatty acids (SCFAs), typically ... The production of bile acids (BAs) is regulated by the farnesoid X receptor (FXR); however, alcohol diminishes ...

After their son’s diagnosis, the Hall family is raising millions for ALD research—giving kids a fighting chance at life.

ALD = alcoholic liver disease; CPT1A = carnitine palmitoyl transferase 1A; CTGF = connective tissue growth factor; DDX5 = DEAD box polypeptide 5; FFA =free fatty acid; HCC = hepatocellular cancer ...

Fatty acids are organic acids with at least one carboxyl (-C(=O)OH, -COOH or -CO2H) group and a long carbon chain that can be joined by double bonds, as in unsaturated fatty acids, or single bonds ...

ALD prevents the body from breaking down very long chain fatty acids (VLCFAs ... treatment options in the next five to 10 years. X-Linked Adrenoleukodystrophy (ALD) is a rare genetic disorder ...

ALD prevents the body from breaking down very long chain fatty acids (VLCFAs) which causes damage to the myelin sheath, the membrane that surrounds nerve fibers in the brain and spinal cord.

What that means is that your overall risk of getting cirrhosis from fatty liver is low, but inflammation greatly increases the chances of serious liver damage. Alcohol-related liver disease (ALD).