In addition, exchanging protons for NMR-silent deuterium helps to simplify spectra. Though this strategy works well for small proteins, it is well-recognized to be ineffective for large proteins.

“TCI Cryo Probe is a proton-optimized triple resonance NMR 'inverse' probe, featuring three fully independent channels (plus ... The TCI Cryo Probe is optimized for 1H and 13C observation. With the ...

One significant advancement in NMR studies is the development of a simple protocol for producing highly deuterated proteins. Deuteration, which involves replacing hydrogen atoms with deuterium ...