In each cell cycle, the integrity of genetic and epigenetic information is challenged during DNA replication. When DNA replicates, chromatin undergoes a wave of disruption and subsequent ...

During DNA replication, the unwinding of strands leaves ... is wrong" and this also holds true for other phases of the cell cycle. In other words, whether ssDNA is created during replication ...

In the course of growth and division, eukaryotic cells duplicate their genomes with remarkable fidelity. The precision of this process depends in large measure upon stringent regulatory mechanisms ...

Harvest cells, want good single cell suspension Count cells Dispense aliquots of 1 million cells into labeled tubes Add 5 ml PBS and centrifuge for 5 min at 400 x g. Re-suspend cell pellet in 300 ul ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

Replication of DNA DNA replication is the process by which a cell makes an identical copy of its DNA. Gene expression Only a fraction of the genes possessed by any particular cell will be expressed.

Nagayama, K. and Hirooka, Y. (2025) Changes in the Mechanical Environment of the Nucleus with Cell Crowding and Its Effects on DNA Damage Resistance. Journal of Biosciences and Medicines, 13, 230-242.

When looking at cells with a microscope, the length of different stages of the cell cycle can be estimated using the formula: \(\text{Length of time in phase}=\) \(\frac{\text{observed number of ...

This image shows the replication cycle of HIV/SIV. The virus replicates in the body's own CD4+ T helper cells. In doing so, it introduces its own genetic information into the DNA of the host cell.

Researchers identify distinct molecular and immune profiles that impact the prognosis of patients with metastatic pancreatic ductal adenocarcinoma.

suggesting that DNA replication problems are critical drivers of genomic instability that promotes aging and tumorigenesis. The Noguchi Lab works with mammalian cells and fission yeast ...