Figure 1: Progression through the mammalian cell cycle. Figure 2 ... CDC6 localization is altered during quiescence. Cyclin A–CDK2-mediated CDC6 phosphorylation has been associated with CDC6 ...

p27 (also known as KIP1, and encoded by CDKN1B) is regulated by multiple signal transduction pathways in normal and malignant cells ... kinases reduces p27–CDK2 inhibition and transforms ...

Blueprint Medicines is cutting funding to its clinical-stage CDK2 inhibitor even as the Ayvakit ... a year after Blueprint dropped two non-small cell lung cancer programs in response to early ...

The company's lead program is a CDK2 inhibitor called INX-315. CDKs refer to cyclin-dependent kinases, which are proteins with a key role in controlling the cell cycle. They have become an ...