The BCR- and TCR-mediated immunological synapses ... The answer may lie, in part, in the innate mechanisms of antigen binding by professional APCs. DCs and macrophages express a variety of lectins ...

In chronic myelogenous leukaemia (CML), a reciprocal translocation between chromosomes 9 and 22 results in a gene encoding BCR–ABL, a fused deregulated kinase that stimulates cellular ...

However, it is unknown how the self-antigens shape the BCR repertoire of B-1 cells, which may function as templates for the selection of antibody specificities. Nevertheless, regulation of the ...