A pathway once considered fundamental in Alzheimer’s disease is being studied intensely again, and may soon result in safer, ...

Over the past few years, data and drugs associated with the amyloid hypothesis have been mired in various controversies relating to data integrity, regulatory approval, and drug safety.

and the 'amyloid hypothesis' suggests they are a primary driver for the neurodegeneration seen in the disease. That viewpoint was severely dented back in 2012, when two highly-anticipated amyloid ...

Drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed to tackle AD ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study.

The amyloid cascade hypothesis, on which many modern Alzheimer's treatments are based, presumes that these fibrils are the cause of the disease. However, emerging evidence suggests that amyloid ...

With that product all-but shelved after reimbursement through Medicare was effectively limited to patients enrolled into clinical trials, supporters of the amyloid hypothesis badly need a win.

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy ...

The errant growth of this protein is responsible for triggering an increase in tangled threads of another protein called tau and the development of Alzheimer’s disease — at least according to the ...