A pathway once considered fundamental in Alzheimer’s disease is being studied intensely again, and may soon result in safer, ...

and the 'amyloid hypothesis' suggests they are a primary driver for the neurodegeneration seen in the disease. That viewpoint was severely dented back in 2012, when two highly-anticipated amyloid ...

Drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed to tackle AD ...

The errant growth of this protein is responsible for triggering an increase in tangled threads of another protein called tau and the development of Alzheimer’s disease — at least according to the ...

Over the past few years, data and drugs associated with the amyloid hypothesis have been mired in various controversies relating to data integrity, regulatory approval, and drug safety.

By the early 1990s, the amyloid cascade hypothesis had emerged, proposing that AD is fundamentally caused by deposition of Aβ protein. The cascade component of the hypothesis captures the idea ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study.

In 1991 John Hardy, a neuroscientist now at University College, London, and his late colleague David Allsop (then at Queen’s University, Belfast) thus proposed the amyloid cascade hypothesis.

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy ...