IRAP (Insulin-Regulated Aminopeptidase): An enzyme that regulates various biological processes, including insulin signaling and peptide metabolism. Allosteric Inhibition: A form of enzyme ...

those given placebo. Treatment with an oral allosteric modulator was nonsuperior to placebo at 6 weeks in adults with Parkinson’s disease whose symptoms included fall risk and cognitive issues ...

Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...