Innovative therapies revive a once-undruggable mitochondrial aging regulator through a revolutionary enzyme activation ...

Controlling protein function rather than protein production has several advantages, including a potentially quicker response to stimuli and the ability to study an enzyme's catalytic function ...

those given placebo. Treatment with an oral allosteric modulator was nonsuperior to placebo at 6 weeks in adults with Parkinson’s disease whose symptoms included fall risk and cognitive issues ...

Farnesyl Diphosphate Synthase (FPPS): An enzyme that catalyzes the synthesis of farnesyl diphosphate, a key intermediate in the mevalonate pathway. Allosteric Inhibitors: Compounds that bind to an ...

While enzyme and allosteric regulation which controls metabolism was suppressed in typical mice during feeding, we were surprised to find that the reverse occurred in obese mice and that this ...