Conclusions This is the first report of a recessive deleterious mutation in CAP2 and its association with DCM in humans ... Our data underscore the importance of the proper kinetics of actin ...

This activity is crucial in that it leads to the elaboration of a branched actin network. The activation of Arp2/3 is under the control of the WASP family and the WAVE family. Another regulator of the ...

Interestingly, genetic syndromes also exist where actin dynamics is upregulated, eg X-linked neutropenia. In this disease, neutrophil levels in blood are low, but there is increased migration of ...

No biological system has been studied by more diverse approaches than the actin-based molecular motor myosin. Biophysics, biochemistry, physiology, classical genetics and molecular genetics have ...

These mutations were conventionally thought to cause disease by altering the force with which each myosin pulls on actin to cause contraction. Recently, however, mutations in the rod domain have been ...

Actin filaments are the smallest type, with a diameter of only about 6 nm, and they are made of a protein called actin. Intermediate filaments, as their name suggests, are mid-sized, with a ...

utas.edu.au Background: The use of reverse transcription-polymerase chain reaction (RT-PCR) to measure mRNA levels has led to the common use of β-actin and GAPDH housekeeping genes as denominators for ...

β-actin is the cell’s most abundant protein, providing shape and allowing them to move. It is fundamental to a number of biological functions. The team say the new disease is caused by gene mutations ...

Other findings included demonstration that the extreme asymmetry of neurons is achieved with a deformable array of interlinked neurofilaments, microtubules and actin. I identified the first ...